A model for cortical remapping and structural plasticity following focal retinal lesions
نویسندگان
چکیده
منابع مشابه
A Model for Cortical Rewiring Following Deafferentation and Focal Stroke
It is still unclear to what extent structural plasticity in terms of synaptic rewiring is the cause for cortical remapping after a lesion. Recent two-photon laser imaging studies demonstrate that synaptic rewiring is persistent in the adult brain and is dramatically increased following brain lesions or after a loss of sensory input (cortical deafferentation). We use a recurrent neural network m...
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Experimental evidence from a number of different preparations indicates that repeated pairing of pre-and postsynaptic action potentials can lead to long-term Long-term modification of synaptic efficacy can de-Spike timing-dependent plasticity (STDP) forces syn-pend on the timing of pre-and postsynaptic action apses to compete with each other for control of the potentials. In model studies, such...
متن کاملA computational model of acute focal cortical lesions.
BACKGROUND AND PURPOSE Determining how cerebral cortex adapts to sudden focal damage is important for gaining a better understanding of stroke. In this study we used a computational model to examine the hypothesis that cortical map reorganization after a simulated infarct is critically dependent on perilesion excitability and to identify factors that influence the extent of poststroke reorganiz...
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Long-term modification of synaptic efficacy can depend on the timing of pre- and postsynaptic action potentials. In model studies, such spike timing-dependent plasticity (STDP) introduces the desirable features of competition among synapses and regulation of postsynaptic firing characteristics. STDP strengthens synapses that receive correlated input, which can lead to the formation of stimulus-...
متن کاملCortical plasticity and its implications for focal hand dystonia.
BACKGROUND The exact origin of focal dystonias has not been elucidated so far. Aberrant plasticity of the brain cortex is suspected to be a crucial factor in the development of this group of movement disorders. The aim of this article is to summarize recent findings on the etiopathogenesis of focal hand dystonias with a focus on the role of abnormal cortical plasticity. METHODS AND RESULTS A ...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2009
ISSN: 1471-2202
DOI: 10.1186/1471-2202-10-s1-p206